Varied Sperm Length Lowers Fertility—Brown Research
Friday, November 16, 2012
“Our study reveals that men who produce higher concentrations of competent swimming sperm also demonstrate less variation in the size and shape of those sperm,” said Jim Mossman, a postdoctoral scholar at Brown University and lead author of the paper. “It suggests that in some cases, testes are working more optimally to produce high numbers of consistently manufactured sperm, and vice versa.”
At the University of Sheffield, where Mossman did his doctoral studies, he and his co-authors measured the heads, midpieces, and flagella of 30 sperm per man, from 103 men randomly selected from a pool of about 500 who were recruited for a larger fertility study. They also measured other characteristics of each man’s semen, such as sperm concentration and motility, that the World Health Organization recognizes as important markers of fertility.
A new look at sperm and size
The WHO suggests that measurements should be made on multiple components of sperm, but generally it’s only the sperm head that is considered,” Mossman said. “No one’s ever looked at this before across sperm components. What we show is that measurements on other sperm parts, such as the flagellum that propels the sperm, can provide additional information about the quality and consistency of sperm manufacture.”
Uniformity more important than length
“The finding could give clinicians new insight into the diagnosis and treatment of male fertility problems, which accounts for up to 50 percent of the cases where couples struggle to conceive,” Mossman said. The research suggests that at least in some men, measurable inconsistency in sperm length may be a sign of trouble with his process of making sperm, a process known as spermatogenesis. That trouble, akin to a manufacturing line with poor quality control, could result in a lower concentration of good swimmers.
“This could be an indirect marker of testis function,” Mossman said.
Mossman acknowledged that there is nothing in the study that suggests what might cause spermatogenesis problems that would result in either inconsistent lengths or low concentrations of motile sperm.
“There are so many factors that govern sperm production, including environmental factors, genetic factors, and their interaction,” Mossman said. “As an andrologist and evolutionary biologist, I am very interested in what causes this variation and how that affects the phenotype of the sperm and its fertility potential.”
At Brown since earning his Ph.D. at Sheffield, Mossman has been working in the lab of David Rand, professor of biology in the Department of Ecology and Evolutionary Biolog, using fruit flies to study the influence of genetics on male fertility. In addition to Mossman, the paper’s other authors are Jack Pearson, Harry Moore, and Allan Pacey, all of the University of Sheffield, which funded the research.
- Cutting Edge in RI: New Fertility Strategies for Children with Cancer
- Ohio Family Travels to Women & Infants for Fertility Preservation for 2-Year Old Daughter
- Women and Infants Participating in National Study of New Fertility Drug
- Women & Infants: Preserving Fertility for Life After Cancer