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NEW: Women & Infants + Brown Pioneer New Down Syndrome Test

Monday, October 17, 2011



A prenatal DNA blood test reduces risks for mothers to be

A major innovation in prenatal screening was announced today by Women & Infants Hospital and Brown University's Alpert Medical School.

A new DNA-based prenatal blood test that can strikingly reduce the number of risky diagnostic procedures needed to identify a pregnancy with Down syndrome is ready to be introduced into clinical practice. The test can be offered as early as 10 weeks of pregnancy to women who have been identified as being at high risk for Down syndrome. These are the results of an international, multicenter study published online today in the journal Genetics in Medicine. The study, the largest and most comprehensive done to date, examined almost 1,700 pregnancies at high risk of chromosomal abnormalities, 212 of which were affected by Down syndrome.

The research was led by Jacob Canick, PhD, and Glenn Palomaki, PhD, of the Division of Medical Screening and Special Testing in the Department of Pathology and Laboratory Medicine at Women & Infants Hospital and The Warren Alpert Medical School of Brown University, and included scientists at Sequenom, Inc. and Sequenom Center for Molecular Medicine, San Diego, CA, and an independent academic laboratory at the University of California at Los Angeles.

The test identified 98.6% of the Down syndrome pregnancies, while only 0.2% of the normal pregnancies were mistakenly called positive. The test rarely failed to provide a clinical interpretation (0.8%).  These findings, along with the detailed information learned from testing such a large number of samples, demonstrate that the new test will be highly effective when offered to women considering invasive testing.

Less invasive, more accurate

“With current screening methods, about one in every 30 women offered a follow-up invasive diagnostic procedure - amniocentesis or chorionic villus sampling (CVS) - will be found to have a pregnancy with Down syndrome.  We expect the DNA-based test to more accurately determine which women should be offered invasive diagnostic testing.  As a result, most of the pregnancies referred for amniocentesis or CVS will be found to have Down syndrome,” said Dr. Canick.

Dr. Palomaki added, “If this new test is used as we’ve described, nearly all women with a normal pregnancy could avoid an invasive diagnostic procedure and its associated anxiety, cost, and potential for fetal loss.

Down syndrome

Down syndrome, also called trisomy 21, is a chromosomal disorder that includes mental retardation, characteristic facial features, and, often, heart defects, and affects one in 550 babies born each year in the US. Down syndrome occurs when each cell in an individual has three rather than the usual two copies of chromosome number 21. Current prenatal screening tests for Down syndrome combine maternal age with information from the measurement of maternal serum markers and ultrasound markers in the first and second trimesters of pregnancy. While these tests can detect up to 90% of Down syndrome cases, they also incorrectly identify 2% to 5% of normal pregnancies as positive. The new DNA-based test will reduce this “false positive” rate while maintaining the detection rate.

Reducing miscarriage risk

“Prenatal screening and diagnosis of Down syndrome has been part of routine prenatal care for decades, and it is estimated that nearly two-thirds of all pregnant women in the US are currently screened,” said Dr. Canick.  “It is possible that with the availability of this new DNA-based test, more women will opt for screening because of the increased safety resulting from far fewer amniocentesis and CVS procedures being performed.”  The US Centers for Disease Control and Prevention estimated in 1995 that about one in every 200 invasive diagnostic procedures will cause a pregnancy miscarriage.

This industry-sponsored project, awarded to Drs. Canick and Palomaki and Women & Infants Hospital in 2008, enrolled 4,500 women at 27 prenatal diagnostic centers throughout the world.  Women & Infants also served as one of the enrollment centers under the direction of maternal-fetal medicine specialist and director of Perinatal Genetics, Barbara O’Brien, MD.

“Screening tests, by their nature, do not diagnose, but rather offer information about the chances that a pregnancy may be affected by a genetic abnormality.  For years we have relied on screening tests that have had a fairly significant false positive rate because that was the best screening available,” said Dr. O’Brien.  “But having access to a DNA-based test that can be done early in pregnancy will give us more information so that we can better guide which patients should consider diagnostic testing.”

Women & Infants on the cutting edge of prenatal screening research

Women & Infants Hospital has been an international center for prenatal screening research. For more than three decades, Drs. Canick and Palomaki have collaborated with others in developing and improving screening tests for Down syndrome and other fetal abnormalities.  In 1988, Drs. Canick and Palomaki were involved in the development of triple marker screening. The team was able to convert its findings into prenatal screening tests now used throughout the world.  Dr. Canick’s lab in 1998 was the first in the US to offer quad marker screening and in the past decade was the laboratory center for the National Institute of Health (NIH) funded FASTER Trial which compared first and second trimester screening.

It was announced today that one version of this laboratory-developed test, MaterniT21, has been validated through clinical studies and is now available through the Sequenom Center for Molecular Medicine, a CLIA-certified and CAP-accredited laboratory.   Harry F. Hixson Jr., PhD, chairman and CEO of Sequenom, Inc., said, “We have been fortunate to partner in the clinical study and are proud to offer the service to assist specialists and high-risk patients in making more informed decisions about their pregnancy."


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The best aspects of finders is there's no limit within the size or shape of the boat you might be using.It means that you are able to use finders about massive vessels, or microscopic one-man boats that will be merely regarding leisure.Focused on to connect the finders to the boat, it's actually a very uncomplicated process, making for much less expensive fuss moment and alot more tracking instance.The finders generally own an instrument that seems a thermometer the fact that drops on the water using a wire and also cord.Whats transmitted from that tool that you choose to place from the water is normally posted about the fish finders filter demonstrating typically the layout plus depth with the lakebed or possibly other the water bodies more affordable depths.

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Comment #3 by aronajuli andeson on 2012 03 20

What is Money?

The answer to the question is simple. Money is anything widely used for paying debts owed by a person to someone else and also for receiving the payments of debts owing to a person from someone else. A country produces coins and banknotes, (accepted by everyone) for the payment of bills and for the receipt of money owing.

Money is what is known as a "medium of exchange".

In the "old days" people traded the goods and services they owned (and probably produced) for goods and services owned by others (probably produced by them). The scenario went something like this - "you give me two sacks of your potatoes and I will trade you ten of my fish".

This method of trading was fine for a while. As society developed, business became more cumbersome and inefficient with this method of trade. Business dealings became stilted and slow and lagged behind the new pace of commerce. There had to be a better way. Some bright spark then came up with the idea of a common "medium of exchange" easier to carry around and better to use.

Money was born.

It wasn't that simple, because while all sorts of things were used as a medium of exchange, these were all basically called "money" and it wasn't until coins and paper notes were developed that money as we know it today became the standard accepted as a medium of exchange.

Forms of Money

There are various forms of money - cheques, IOU's, credit cards, bank drafts or gold. Gold was the standard used in the past because of its scarcity and its qualities. Gold is resistant to corrosion or damage. These unique properties, as well as the scarcity of gold means that even today, wealthy people around the world would rather keep their wealth in gold holdings than in the currencies of countries which are subject to inflation.

In fact, all sorts of things have been used as money throughout the ages. Some include: beads, eggs, salt, pigs, leather, yarn, axes, ivory and jade. Today we have another form of money, which cannot be touched, and yet it as real as the tangible coins we are able to touch. This form of money is electronic money.

The Name "Money"

The word money comes from the Roman goddess - Moneta. Apparently coins were minted in her temples and issued to the world, as the Romans knew it at the time. The Latin word "Moneta", (meaning mint or coins) came from the old English word "mynet" (meaning coins or money) and from this came the English word "mint".

Origins of Money

To understand the origins of money we have to go back to a time well before money came on the scene. Money did not suddenly appear - it was introduced gradually in response to the requirements of human needs. As civilization grew and expanded beyond local societies, the need to exchange the products provided by various groups became evident. The hunter needed to exchange with the farmer, the shepherd needed to exchange with the medicine man etc.

The medium of exchange that was necessary to enable the various groups to barter and swap their products was money. It was originally a physical substance like gold or silver. Sometimes it was a substance that was alive such as cattle, which was one of the oldest forms of money.

Today, although much of the money used by individuals in their everyday life is still in the form of notes and coins, its quantity is relatively small compared to the intangible types of money existing as entries in bank records.

Today money exists in the form of digital cash and such things as coins and bank notes will soon become obsolete. When this happens, the change in the nature of money will have a significant effect on our society.

Comment #4 by eritlefeli andeson on 2012 03 22

There appear to be an continual stream for idiotic items professional athletes do.I guess once you put several young men together, give them a boat-load regarding money and much free occasion, what could you expect? Anytime beautiful wives, the media and also luxuries of life are usually thrown at them, their cockiness and additionally stupidity are merely amplified.Here's my top ten, but naturally you'll find plenty more.Yet, we should always remember, they're just only real human too.

1.My family Make Wonderful Play!

Ever see NFL participants beat their chest as a gorilla as soon as they just made a good quality play? Just maybe it's a fabulous Tarzan thing or one thing, but individuals look kinda ridiculous.Maybe just was around on the actual field along with I appeared to be a 170-pound kicker monitoring a preserving lineman whipping his chest looking for a sack, I would be a little intimidated, however , overall, they check really silly undergoing it.(I attended a competent all-women's football game this coming year and noticed a 350-pound woman execute this, which was first particularly scary.)

a pair of.The Our god Factor, Piece I

I never enjoy it anytime players point as many as Heaven along with thank God after having a good have fun too.Do not forget however, we am not likely criticizing religious beliefs or someone for getting faith throughout God.However , this only just looks lame.It happens a good deal in MLB for reasons unknown.A strikeout will result in Pedro Martinez to perform the chest-touch and also double-index-finger-point in order to God because if he and God are chatting prior about probable pitching strategies on the locker area, and all the strategy they chose with each other worked, so he previously to really thank Jesus using their direct range.

3.Any God Matter, Part II

Locker places, sidelines, dugouts, bullpens, and in the court sides are usually full regarding praying males.One problem:"If that you're praying for you to win, with your opponent is normally praying to make sure you win, who God consider?

3.Bad Guys, Bad Guys, Whatcha Visiting Do As soon as they Come In your case?

Why implement pro jocks get arrested regarding drug and/or gun possession a huge amount of? Of tutorial, lots of folks do this one unfortunately, we just should hear regarding the famous sportsmen who do.C'mon individuals, keep all the drugs in your house, stop operating while superior, and just for crying aloud, stop packin'! You don't have a handgun.Who's attending harm you will? You're six to eight six and additionally weigh 275 excess weight!

5.It all Wasn't Others!

Telling Congress one doesn't do steroids, consequently getting seen doing steroids is pretty foolish.I preferred watching the clips in which Rafael Palmero sat pointing a new finger within the Congressional seeing and hearing stating through disgust not to mention confidence, "I really don't take steroids." After which you can the after that clip displaying him apologizing profusely to look at steroids.

6.Im a sucker for You To make sure you Death

Murdering ex-lovers will not happen oftentimes fortunately, but great list wouldn't be full without as a minimum mentioning A.J.


It looks that several of NBA players nowadays who use the phrase, "My infant's mom" a touch too often.And there's many pro athletes' offspring introducing their particular buddies as "My close friend from a further mother." Truly hear associated with a condom?

8.How A whole lot Bling Bling Can you use!?

It's fascinating to observe professional athletes blow through of their millions with their first couple of years and in that case have nothing at all left with retirement, which is typically few years subsequently.How various fifty-year-olds are nevertheless playing professional player sports? Not so many (minus golfers naturally, who will drag their particular canes as well as oxygen tanks with these on the fairway).So what say we pro triathletes save two or three bucks?

9.Really enjoy My Hog

It's not at all too wise to get injured amazing job while you're a pro athlete.Cleveland Browns Kellen Winslow Junior.crashed the motorcycle recently and definitely will now lose the 2005 NFL season.The author Williams, numerous one pen pick in the Chicago Bulls, also experienced a motorcycle accident and possesses not performed since.What the heck is with motor bikes anyhow? Focus on killing all the goose which usually lays any golden eggs.

10."When You Found yourself in a Fork inside Road, Require It" - Yogi Berra

Saying truly dumb things on the media appear to be a primarily easy course of action if you're a competent athlete.I looked in a great deal of places online to get a very good list listed here.My condition was that they had so numerous good versions, I hasn't been sure which of them to select.But read on for some gems:

a good.Paul Hamm, Gymnast:"I owe significantly to great parents, especially my parents."

d.Baseball gamer Tito Fuentes, after possessing hit by just a pitch:"They needn't throw located at me.I'm the daddy of four or five kids."

j.Football instructor Ray Malavasi:"I usually do not care the things the tape says.THAT I didn't tell you it."

ve had.Baseball gamer Dizzy Dean, after the 1-0 sport:"The sport was closer ?n comparison to the score showed."

orite.Boxing Analyzer:"Sure we have witnessed injuries, and some demise in boxing, but carry out really which usually serious."

f ree p.Soccer commentator:"Julian Dicks is certainly everywhere.It's like they are forced eleven Dicks for the field."

f.Bill Cowher, Pittsburgh Steelers train:"We're not endeavoring to circumcise recommendations."

they would.Jim Wohford:"Ninety percent within the game is normally half intellectual."

that i.Joe Theismann:"Nobody throughout football has to be called a genius.A genius may be a guy like Norman Einstein."

m.Charles Shackleford within the NCSU hockey team:"Left present, right side, it shouldn't matter.I will be amphibious."

ok.Shaquille O'Neal, on his scarcity of championships:"I've triumphed in at just about every single level, except for college and additionally pro."

When i already quizzed before, so what can we believe from professional athletes? They quite often reflect society as one.Too long, money and additionally fame on a really adolescent age may augment ignorance, simple while that.Every person say and additionally do dumb things, however , thankfully, we lack microphones and camcorders pointed with us regularly.As Grettle Einstein useful to say, "Really smart athletes refrain from problems given that they can predict the destiny with their ESPN.inch.

Comment #5 by aieserpasscott andeson on 2012 03 23

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Sometimes last-minute deals are offered only in particular a short time (for situation weekends) and only couple of destination parts.You should check these websites out to work out if your neighborhood is listed for the special delivers list.If everyone cant see one large amount at an individual website searching on several other websites on top of that.There are a great number of travel websites nowadays that sometimes it gets to be confusing and even difficult to pick out at least one.But certainly spending a while online can help you see the ones that of these individuals are worthy of your setting, budget as well as travel weeks.

For everybody who is in speed then driving towards nearest flight terminal and checking for last-minute reservation deals will end up being useful.Bear in mind that last-minute deals are offered anywhere somewhere between 3 working hours to fortnight before all the flight.So it will not really show that if you're approaching typically the airport a small amount of earlier than final, you can't get a good price.Therefore, focus on to verify the web-sites first previously booking.

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If you desire a extraordinary last-minute deal for just a holiday holiday, such for skiing or about to play the game, then hone down ones own search or take advantage of the keyword browse facility offered by these internet websites.Last-minute packages really do not normally feature individual deals for commercial airline travel and / or hotel some worries.As already stated, you have to buy an entire package among them airfare and additionally hotel holiday accommodation and many times including car on top of that.So approach your holiday accordingly so you can benefit wholly from such offers.

Comment #6 by aieserpasscott andeson on 2012 03 23

Getting wholesale video game titles today gets in most rising entrepreneurial opinions and practically in most home interesting bargain shopping seekers-faster not to mention easier prior to now.The ordinary when looking for games from good low-cost prices is to visit to the nearby Sam Club and get a couple games at as an example the $13.36-$19.86 prices i see quite often here inside the states.I still see regional businesses assume that the obvious way to get good buy cheap items is by simply buying low cost from basic local wholesalers plus liquidation centers.

For the standard businessman that will not like to undertake their very own diligence for getting entertainment games within the greatest from suppliers prices- its fine plus ok purchasing locally every week or almost every other month.Nothing bad to be able, but that may be enough for anyone who is a at wholesale prices addict just like myself and / or an additionally entrepreneur like a number of us that really like playing System wholesale games whilst getting to make a lot of money every month within the comfort in home together with having several tangible internet business offline not to mention online.The businesses that need the most sources, the most prices along with the best at wholesale prices business relationships to get wholesale gaming systems need deals to good deal prices towards profit constantly.Plus normal retail business enterprise both on the internet and internet need any entertainment in-demand product for equally home not to mention consumer romantic relationship.Take good thing about this, become a fabulous re-seller- this can be a great solution also.

Today final savings get trickier and online business indeed gets extra stronger but greater than ever.It truly is of the fact, that appropriate wholesale sources for you to get- the superior business you will be able to build because regarding selling during what I love to call, low cost prices.The truth is, the majority from the wholesale organization sell with regards to getting the 20-30% mark-up every time they can obtain a comfortable 50-80% if receiving the mentality that the home amusing needs along with online not to mention offline online business profits get made as you make the initial wholesale choose, not after you sell the product.

Whether you get buying real estate investment, DVDs, audio or maybe what I love to sell both equally online together with offline, games located at wholesale prices- people make an individual's profits after you buy from certain vendors and wholesalers, not after you sell.The earnings are always subject to how low you pay for and precisely what service anyone ultimately provide on the subject of the sell off of concrete items each of those locally and via the internet.It is normally evident in addition to clear that will my purse that the prospect of selling pertaining to say:Xbox below wholesale games at really cheap prices, will not likely depend solely within the service, image and also credibility you could have as a good brand- nonetheless generally towards average customer, it stands out as the price you offer as well as low risk version of guaranteed that should have these craving for the wholesale mmorpgs business.

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Comment #12 by aronajuli andeson on 2012 03 28

When you have a child, or even before you do, start collecting gold coins. When your child grows up, cash them in to send your high school graduate to the University of their choice. Your child can do the same for your grandchild. Collecting gold coins can make something special for your family. It can make your family special. Even rich and famous. Can it be done? Has it been done? Well, do you recognize any of these family names?

If you have heard of the Adams family, or the Brand family, or the Dupont family, or the Royal Farouk family, or the Garrett family, or the Green family, or the Hopkins family, or the Hunt family, or the JP Morgan family, or the Onassis family, or the Rothchild family then there is a good reason why. They built their fortunes from collecting gold coins.

Take for instance Mayer Amschel Rothschild. He worked in a coin shop, which made the way for the Rothschild's destiny as the richest family in the world. Because it is there that he learned the value of collecting gold coins. That is how he made his fortune. That is how he was able to open a bunch of banks.

People were getting so outrageously rich from gold coins that the government just had to step in and take them away. And the gold bullion and gold certificates too! If you owned them you were an outlaw. If you didn't turn them in you had to go to jail for ten years and pay twice the value of your gold plus ten thousand dollars on top of that. Thanks to the gold confiscation of April 5th 1933 by the Executive Order 6102 of President Franklin D. Roosevelt, the government had to build Fort Knox to hold its enormous collection of gold!

The people of our land of opportunity have been denied this most lucrative investment for forty-one years until... the last day of December 1974. That is when President Gerald R. Ford signed the bill authorizing private ownership of gold. Happy days are here again! Gold is legal again!

In 1795 the United States minted its very first gold coin. The five-dollar Gold Half Eagle featuring Lady Liberty. Before President George Washington got our government its first mint, we used gold doubloons. A favorite of pirates, who were a liberty loving lot indeed!

We all like money. We all like gold. Gold coins bring them both together in one pretty package. Buy gold coins, whether for hobby or investment. They give the best return due to their limited quantity, timeless beauty, gold content, and high demand.

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